您好!欢迎来到Lifesci mall生命科学商城!

客服电话

400-9961-933

当前位置: 首页 > 抗体 > 磷酸化抗体 > Bub3 (Phospho-Tyr207) Antibody

最近浏览过的商品

Bub3 (Phospho-Tyr207) Antibody

Bub3 (Phospho-Tyr207) Antibody

  • 商品品牌:AbSci
  • 商品货号:AB11586
  • 货期: 预计到货1-5
货号 规格 价格
AB11586-1 50ul ¥1450 元
AB11586-2 100ul ¥2250 元
购买数量:
  • 商品介绍
  • 商品描述
  • 商品相册
Primary Antibody
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
applications WB
Application Details

 Western blotting: 1:1000

Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of Bub3 only when phosphorylated at Tyrosine 207.
Target Name Bub3
Alternative Names Mitotic checkpoint protein BUB3, Hbub3, BUB3L, BUB3 budding uninhibited by benzimidazoles 3 homolog, budding uninhibited by benomyl
Accession No. Swiss-Prot#: O43684 NCBI Protein#: NP_001007794.1
Modification Phospho-Tyr207
SDS-PAGE MW 40KD
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around phosphorylation site of Tyrosine 207 (V-E-Y(p)-L-D) derived from Human Bub3.
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore Store at -20°C/1 year
Background
Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1.

 

 

Seeley T.W., Wang L., Zhen J.Y.Biochem. Biophys. Res. Commun. 257:589-595(1999)

Tang Z., Shu H., Oncel D., Chen S., Yu H.Mol. Cell 16:387-397(2004)

Logarinho E., Resende T., Torres C., Bousbaa H.Mol. Biol. Cell 19:1798-1813(2008)

 
Host Species Rabbit

用户评论

(共0条评论)
  • 暂时还没有任何用户评论
总计 0 个记录,共 1 页。 第一页 上一页 下一页 最末页
用户名: 匿名用户
E-mail:
评价等级:
评论内容:
验证码: captcha
版权所有 2005-2017 南京川博生物技术有限公司(Lifesci mall生命科学商城) All rights reserved
公司地址:江苏省南京市浦口国家高新区星火路10号 电话: 400-9961-933 | E-mail: info@lifescimall.com
增值电信业务经营许可证: 苏B1-20150380 苏ICP备15009006号-2
本商城logo和图片都已申请保护,未经授权不得使用。本商城承诺不会将顾客信息泄漏给任何第三方机构和个人。
有任何购物问题请联系我们在线客服。
  • 电话咨询

  • 400-9961-933