您好!欢迎来到Lifesci mall生命科学商城!

客服电话

400-9961-933

当前位置: 首页 > 抗体 > 总抗 > p53(Ab-15) Antibody

最近浏览过的商品

p53(Ab-15) Antibody

p53(Ab-15) Antibody

  • 商品品牌:AbSci
  • 商品货号:AB21085
  • 货期: 预计到货1-5
货号 规格 价格
AB21085-1 50ul ¥1000 元
AB21085-2 100ul ¥1500 元
AB21085-4 25ul ¥600 元
购买数量:
  • 商品介绍
  • 商品描述
  • 商品相册
Primary Antibody
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
applications WB IHC IF
Application Details

Predicted MW: 53kd

Western blotting: 1:500~1:1000

Immunohistochemistry: 1:50~1:100

Immunofluorescence: 1:100~1:200

Species Reactivity Human
Specificity The antibody detects endogenous level of total p53 protein.
Target Name p53
Alternative Names Tumor suppressor p53; Phosphoprotein p53; Antigen NY-CO-13; TP53;
Accession No. Swiss-Prot: P04637
NCBI Protein: NP_000537.3
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.13~17 (P-L-S-Q-E) derived from Human p53.
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Background

p53 is a nuclear protein which plays an essential role in the regulation of cell cycle specifically in the transition from G0 to G1. It is found in very low levels in normal cells however in a variety of transformed cell lines in high amounts and believed to contribute to transformation and malignancy. The open reading frame of p53 is 393 amino acids long, with the central region (consisting of amino acids from about 100 to 300) containing the DNA-binding domain. This proteolysis-resistant core is flanked by a C-terminal end mediating oligomerization and an N-terminal end containing a strong transcription activation signal. p53 binds as a tetramer to a PBS (p53-Binding Site) and activates the expression of downstream genes that inhibit growth and/or invasion. p53 binds as a tetramer to a p53-binding site (PBS) and to activate the expression of adjacent genes that inhibit growth and/or invasion. Deletion of one or both p53 alleles reduces the expression of tetramers, resulting in decreased expression of the growth inhibitory genes



Lin T, et al. (2005) Nat Cell Biol; 7(2): 165-71.

Vega FM, et al. (2004) Mol Cell Biol; 24(23): 10366-80.

Li J, et al. (2004) J Biol Chem; 279(40): 41275-9.

Wang J, et al. (2004) J Biol Chem; 279(38): 39584-92.

Host Species Rabbit

用户评论

(共0条评论)
  • 暂时还没有任何用户评论
总计 0 个记录,共 1 页。 第一页 上一页 下一页 最末页
用户名: 匿名用户
E-mail:
评价等级:
评论内容:
验证码: captcha
版权所有 2005-2017 南京川博生物技术有限公司(Lifesci mall生命科学商城) All rights reserved
公司地址:江苏省南京市浦口国家高新区星火路10号 电话: 400-9961-933 | E-mail: info@lifescimall.com
增值电信业务经营许可证: 苏B1-20150380 苏ICP备15009006号-2
本商城logo和图片都已申请保护,未经授权不得使用。本商城承诺不会将顾客信息泄漏给任何第三方机构和个人。
有任何购物问题请联系我们在线客服。
  • 电话咨询

  • 400-9961-933