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CDC25A(Phospho-Tyr59) Antibody

CDC25A(Phospho-Tyr59) Antibody

  • 商品品牌:AbSci
  • 商品货号:AB11598
  • 货期: 预计到货1-5
货号 规格 价格
AB11598 50ul ¥1450元
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Primary Antibody
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
applications WB IHC
Application Details

Western blotting: 1:500~1:1000


Immunohistochemistry: 1:50~1:100

Species Reactivity Hu
Specificity The antibody detects endogenous level of cdc25A only when phosphorylated at tyrosine 59.
Alternative Names CDC25M3, MPIP1
Accession No. Swiss-Prot#: P30304
NCBI Gene ID: 993
NCBI Protein#: NP_001780.2
Target Species CDC25A
Modification Phospho-Tyr59
Calculated MW 70kd
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around phosphorylation site of tyrosine 59 (S-D-Y(p)-E-Q) derived from Human CDC25A.
Concentration 1.0mg/mL
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore Store at -20°C
Background



Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDC2 and stimulates its kinase activity. Also dephosphorylates CDK2 in complex with cyclin E, in vitro.


Jin J, et al. (2003) Genes 17(24): 3062-74.

Shimuta K, et al. (2002) EMBO J 21(14): 3694-703.

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