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TrkB(Phospho-Tyr705) Antibody

TrkB(Phospho-Tyr705) Antibody

  • 商品品牌:AbSci
  • 商品货号:AB11328
  • 货期: 预计到货1-5
货号 规格 价格
AB11328-1 50ul ¥1450 元
AB11328-2 100ul ¥2250 元
AB11328-4 25ul ¥850 元
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  • 商品描述
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Primary Antibody
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
applications WB
Application Details

Predicted MW: 140kd

Western blotting: 1:500~1:1000

Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of TrkB only when phosphorylated at tyrosine 705.
Target Name TrkB
Alternative Names BDNF/NT-3 growth factors receptor precursor; EC 2.7.10.1; GP145-TrkB; GP145-TrkB/GP95-TrkB; NTRK2
Accession No. Swiss-Prot: Q16620
NCBI Protein: NP _001007098.1
Modification Phospho-Tyr705
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around phosphorylation site of tyrosine 705 (T-D-Y P-Y-R) derived from Human TrkB.
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Background

Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.



Woronowicz A, et al. Glycobiology. 2007 Jan;17(1):10-24.

Mojsilovic-Petrovic J, et al. J Neurosci. 2006 Sep 6;26(36):9250-63.

Lewis MA, et al. Mol Pharmacol. 2006 Apr;69(4):1396-404.

Cai D, et al. Physiol Genomics. 2006 Feb 14;24(3):191-7.

Host Species Rabbit

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