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GSK3α/β(Phospho-Tyr279/216) Antibody

GSK3α/β(Phospho-Tyr279/216) Antibody

  • 商品品牌:AbSci
  • 商品货号:AB11301
  • 货期: 预计到货1-5
货号 规格 价格
AB11301-1 50ul ¥1450 元
AB11301-2 100ul ¥2250 元
AB11301-4 25ul ¥850 元
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  • 商品描述
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Primary Antibody
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
applications WB IHC IF
Application Details

Predicted MW: 46, 51kd

Western blotting: 1:500~1:1000

Immunohistochemistry: 1:50~1:100

Immunofluorescence: 1:100~1:200

Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of GSK3α/β only when phosphorylated at tyrosine 279/216.
Target Name GSK3α/β
Alternative Names Factor A; GSK-3 alpha/beta; kinase GSK3-alpha/beta
Accession No. Swiss-Prot: P49840/P49841
NCBI Protein: NP_063937.2/NP_001139628.1
Modification Phospho-Tyr279/216
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around phosphorylation site of tyrosine 279/216 (V-S-Y(p)-I-C) derived from Human GSK3α/β.
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
StorageStore Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Background

Participates in the Wnt signaling pathway. Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN. Phosphorylates JUN at sites proximal to its DNA-binding domain, thereby reducing its affinity for DNA. Phosphorylates MUC1 in breast cancer cells, and decreases the interaction of MUC1 with CTNNB1/beta-catenin. Phosphorylates CTNNB1/beta-catenin.



Chin PC, et al. Brain Res Mol Brain Res 2005 Jun 13; 137(1-2): 193-201

Takahashi-Yanaga F, et al. Biochem Biophys Res Commun 2004 Apr 02; 316(2): 411-415

Fan G, et al. J Biol Chem 2003 Dec 26; 278(52): 52432-52436

Liao X, et al. Mol Cancer Ther 2003 Nov; 2(11): 1215-1222

Host Species Rabbit

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